Dogs with this inherited condition usually look and act perfectly healthy, but sadly, they can die without warning. If you own one of these popular breeds, know the red flags and ask your veterinarian about the genetic testing that’s now available.
The researchers analyzed thousands of Newfoundland genes to identify the mutation associated with SAS. The mutation occurs in the phosphatidylinositol-binding clathrin assembly protein (PICALM) gene. Interestingly, according to Dr. Stern, this is the same gene mutation that has been linked to the development of plaque-like lesions in the brains of Alzheimer’s sufferers.
“Our hope now is that breeders will be able to make informed breeding decisions and avoid breeding dogs that harbor this mutation, thus gradually eliminating the disease from the Newfoundland breed,” Stern said in a university news release.2
Symptoms of SAS
In mild cases of subvalvular aortic stenosis, there are typically no observable clinical signs of disease.
In some moderate cases, and almost all severe cases of SAS, symptoms include difficulty breathing, weakness, fainting, and in extreme cases, sudden death. According to Cornell University College of Veterinary Medicine, we must “Realize that dogs with subaortic stenosis, even severe subaortic stenosis, may look perfectly healthy and active. These dogs generally do not realize that their hearts are compromised.”
The median survival time for dogs with severe SAS who do not receive treatment is 19 months. For dogs receiving traditional treatment (beta-blockers), the median survival is 56 months. Most dogs with the severe form of the disease die before they reach 4 ½ years of age. Dogs with mild to moderate SAS usually do much better, with some living a normal lifespan.
Diagnosis involves a thorough physical exam, including using a stethoscope to listen for a heart murmur or irregular heartbeat. Your veterinarian will also want to know if your dog has displayed any of the symptoms typical of SAS.
Chest x-rays will be performed to check for fluid accumulation in the lungs. An electrocardiogram (ECG) may also be done to look at the electrical activity of the heart and check for arrhythmias.
An echocardiogram (cardiac ultrasound) is the diagnostic test of choice for SAS, because it allows your veterinarian or veterinary cardiologist to visualize the inside of the heart to assess the heart valves, blood flow patterns and velocity, extent of blockage, and severity of disease (mild, moderate, or severe), and other details of the heart’s structure and function.
In mild cases of the disease, treatment is not required. However, since subvalvular aortic stenosis can worsen as a young dog matures, animals with moderate to severe disease may require medication.
To reduce the workload on the heart and avoid symptoms, these dogs should also be prevented from engaging in sudden bursts of activity or intense physical exertion.
Follow-up appointments with your veterinarian are important to monitor your pet’s progress, adjust treatment as necessary, and to insure your dog is as comfortable as possible.
If medications are being given, periodic echocardiograms may be performed to customize the therapy as necessary.
If your dog is having trouble breathing or collapses, it’s important to get to your veterinarian or the local veterinary emergency clinic immediately, even if your dog recovers quickly from the collapse.
Though rare, SAS also occurs in human children, and one treatment option is surgery to remove the ridge or ring of abnormal tissue below the aortic valve. This procedure has been tried with dogs, but has not increased survival rates according to Dr. Stern of UC Davis. In addition, open-heart surgery for dogs is only available at a handful of centers worldwide.
Cutting Balloon Valvuloplasty: A Procedure with Promise for Dogs with Severe SAS
Several other types of surgical procedures and balloon catheterization procedures have been performed in dogs with SAS, with inconsistent results. However, more recently veterinarians at the University of Florida Veterinary Teaching Hospital have had some success with a technique using cutting balloon valvuloplasty for dogs with severe disease.
Genetic Testing Is Now Available
Genetic testing for presence of the PICALM mutation is available through North Carolina State University’s College of Veterinary Medicine and the Veterinary Genetics Laboratory at the UC Davis School of Veterinary Medicine.
Going forward, now that scientists know one gene is responsible for SAS and which proteins are involved, they will be working to develop novel therapies to help treat dogs with the disease.
The researchers are also now studying the differences in severity of the disease, and the genetic basis of SAS in Golden Retrievers, Rottweilers, and other breeds.
Thanks to Dr. Karen Becker for sharing her article.